Crystal Structure of Ritonavir Form IV and Thermodynamic Relationships between Ritonavir Polymorphs
Varda Collaboration
Stephan D. Parent, Jared P. Smit, Dale K. Purcell, Pamela A. Smith, Pierre Le Maguerès, Haley C. Bauser, and Adrian Radocea
Abstract
The crystal structure of Ritonavir Form IV is reported. The structure was determined by electron diffraction, and the molecular conformation and hydrogen bonding show similarities to those of Forms I and III. Form II is shown to be the most thermodynamically stable of the four known polymorphs.
Published in
ACS Publications
Publishing date
Jan 23, 2026
About Varda
Varda is designing and building the infrastructure for pharmaceutical companies to synthesize novel molecules in microgravity.