Nirmatrelvir methyl tert-butyl ether solvate
Varda Collaboration
Jared P. Smit, Dale K. Purcell, David A. Engers, Pamela A. Smith, Haley C. Bauser and Adrian Radocea
Abstract
The structure of nirmatrelvir MTBE solvate, C23H32F3N5O4·C5H12O, at 150 Khas monoclinic (P21) symmetry. The asymmetric unit contains one nirmatrelvirmolecule and one methyl tert-butyl ether solvent molecule. The extendedstructure consists of N—H� � �O hydrogen bonds that create create [010] chains.Crystals of the title compound were grown from various methyl tert-butyl ether–methanol solvent mixtures, with crystal morphology dependent upon themixture ratio.
Published in
Acta Cryst. (2026). E82, 477–479
Publishing date
Apr 14, 2026
Canonical URL
https://doi.org/10.1107/S2056989026003816About Varda
Varda is designing and building the infrastructure for pharmaceutical companies to synthesize novel molecules in microgravity.